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In 2017, a couple of landmark studies defined disease-associated microglia (DAM

doi: 10.1089/ars.2013.5674 77 Sukumari-RameshSPrasadNAlleyneCHVenderJRDhandapaniKM

doi: 10.1016/j.ecoenv.2024.115995 50 MaQAugustoDGMontero-MartinGCaillierSJOsoegawaKCreeBACet al

Mokrzynski, K

Gut 42 , 485492 (1998)

This exhaustion is driven by transcription factors such as FOXO1, 488 FOXO3, and TOX and is further reinforced by epigenetic modifications involving DNMT3A, EZH2, and HBO1 489,490 (Fig